in a study that demonstrated the power of music as an antidepressant agent was divided a group of severely depressed people into three smaller groups. The former received weekly visits from a therapist music they played music and taught stress management techniques. The second group was provided with recorded music to be heard on their own. Finally, the third group was not provided music. It found that people in the first two groups (ie those who listened to music) significantly improved their mood, what did not happen with the group not exposed to music.

In January 2008, the Cochrane Database of Systematic Reviews, published an analysis of five studies on the use of music therapy on patients with depression. This was done by a group of researchers led by the . In four of these studies, a reduction in symptoms of depression among patients undergoing music therapy. In the fifth, there was no difference between those who received music therapy treatment and those who did not receive them. An important fact is that in the four studies that yielded positive results of music therapy interventions were carried out following a clear theoretical while the other study did not seem to have a clear vision of why the therapists were doing treatment or the theory behind it.

in April 2009 explored the findings of 23 studies and found that the evidence shows that music therapy may help lower blood pressure, heart rate and anxiety levels of cardiac patients. We also found some improvement in mood, these patients but found no improvement in heart patients suffering from depression caused by his heart condition. One thing that may be important is that the vast majority of these studies used prerecorded music. However, many researchers think that the music offered by a trained music therapist can offer superior benefits. In the case of heart patients is thought that the beneficial results of the music are the result of its ability to reduce stress. Since there is a close relationship between stress and depression is reasonable to think that music therapy could be helpful in the prevention and treatment of depression.